Neuromodulation Technology - Health and Wellness Without Drugs or
Avazzia manufactures FDA cleared microcurrent Biofeedback Electro
Stimulation Technology (BEST) devices which feature non invasive neuromodulation. This system is based on
easily understood concepts: neuro means nerve and modulation
means varying the property of a wave or signal. Thus, put together it means changing the signals of
The human body
has three systems for functioning: chemical (changing food into energy, for instance), mechanical (bones and
muscles) and electrical (the heart beat is but one example
which is why
pacemakers are electrical devices).
devices, all engineered and manufactured in Dallas, TX, use proprietary software and microchips in its
neuromodulation applications. This non pharmaceutical, non invasive technology is designed to stimulate the
body’s natural release of nitric oxide, endorphins and neuropeptides into the blood stream.
causes vascular dilation and thereby increases blood circulation. This is critical to wound healing, reduction
of edema and treatment of diabetic neuropathy.
Endorphins are the body’s
natural pain management chemicals.
the body’s regulatory elements that promote accelerated healing.
electrical signals, different than other TENS signals, allow this to happen because:
They are short duration pulses of high voltage amplitude and very low
The average currents are in the micro current range.
These are damped biphasic, sinusoidal waveforms.
The process is further enhanced by signals that change and adapt as the
electrical properties of
the tissue being treated change (biofeedback read-
stimulate the neuro endocrine system through direct touch to
the skin. The
BEST™ device electrodes (onboard or through accessories)
can detect (via
biofeedback) impedance on skin by “sticking” (dramatic in-
friction) to acupuncture or electron deficient sump points when glid-
instrument over the skin.
areas may be injured or diseased tissue or may be associated
with an organ or
corresponding body system. By placing the BEST™ elec-
trodes at a
correct spot for treatment, equilibrium between tissues and organs
is restored, and
the redox (reduction oxidation) potential of the body is re-
research has identified the electrical signal characteristics
that impact “C”
fibers, resulting in the stimulation of nitric oxide, hormones,
neuropeptides. Other publications indicate the signal charac-
treatment locations that balance the sympathetic and parasym-
signal properties are attained by using Avazzia’s proprietary algorithms that produce specific patterns of
output pulses for specific applications.
AVAZZIA technology quickly provides relief of chronic and other pains.
The pain relief is long lasting, up to 12 hours, and frequently longer.
through its biofeedback feature, modifies waveforms to eliminate habituation or accommodation by the body.
BEST is a non
invasive microcurrent system that transcutaneously communicates with the internal peripheral nervous system for
the purpose of therapeutic intervention.
microprocessors, unknown when electro stimulation technology was initially created, establish a cybernetic loop
between the BEST device and the body. The body’s response is measurable, creating information for the loop. When
a signal is emitted and
into the tissue, the impedance of the tissue (analogous to resistance in DC circuits but dynamic in nature)
modulates the next waveform. The degree of modulation is based upon the changes of impedance of skin. This sets
up a constantly changing interactive bio loop processing non repeating signals.
change in impedance diminishes in significance until a plateau occurs.
The three charts
(below) show Avazzia waveforms of tissue first being treated, midway through treatment and finally, when tissue
impedance diminishes and treatment stops.
not just another TENS
developed for the control of chronic and post operative pain by saturating subcutaneous nerve receptors with low
intensity electrical stimulation. TENS deliver constant voltage with fluctuating current and
resistance/impedance. BEST™ delivers a driving signal based upon the change in microcurrent and impedance over
the active pulse interval. Unlike TENS, which relies on constant and externally generated signaling principles,
BEST™ is based upon the development of a cybernetic feedback loop.
work on the pain gate theory by applying a saturating electrical charge to the A and B fibers of the nervous
system, thereby blocking the pain message to the brain. Once the stimulation is removed, the pain often returns
a short time later.
(Biofeedback Electro Stimulation Technology) devices generate electrical impulses that are similar to
neurological impulses in the C nerve fibers. These fibers are embedded in tissues and make up 85 percent of all
nerves found in the body and to “fast” pain blocking A fibers.
History of TENS
can be divided into four eras: early TENS; second generation TENS; third generation (interferential) TENS; and
interactive biofeedback TENS.
developed in the 1930s had Mono phasic square wave signals and worked at 10 to 500 mA (milliAmpere). This
technology has serious drawbacks: habituation (it treated pain for several weeks, after which time the body
accommodated or habituated to the stimulation and no longer blocked pain). The other serious drawback was its
short period of pain relief (less than one hour). Even though this technology is obsolete, it is still used
today and frequently is the only experience patients have with TENS.
for this group, developed in the 1970s, has an asymmetrical biphasic square wave output. Biphasic means the
signal goes plus and minus relative to a reference voltage.
means the plus and minus signals are not equal in time of application and/or voltage.
over early TENS is that habituation is reduced. Even so, pain relief still is brief (less than an hour). Again,
this obsolete technology is still widely available and used today.
was subsequently developed with asymmetrical, biphasic, and irregular shaped, microcurrent wave outputs. These
waveforms result in partial opioid mode and partial pain gate mode. Opioid mode means that the electrical
stimulation results in the production by the body of endogenous opioid peptides which mitigate pain. Pain gate
mode means the A and B nerve fibers are stimulated to inhibit an individual’s perception of pain. This
technology improves the duration of pain relief while reducing the likelihood of habituation. This technology is
widely used today.
technology, implemented by Avazzia in its premier line of BEST products, incorporates the latest understanding
in microcurrent and neuromodulation. It was learned that:
high voltage (>250 volts), low
cycle (<10%), microcurrent signals were more effective in stimulating the thin C fibers of the
nervous system than square wave signals.
asymmetrical wave form reduces habituation.
use of electrical biofeedback to adjust the waveform as the electrical properties of the tissue being treated
changes further reduces habituation and allows the technology to measure the progress of the treatment and provides
information to the medical practitioner.
wave signals more closely approximate the natural signals in the nervous system.